watch dogs.pc.game.skidrow torrent download.Immunological potential in chronic bronchitis: studies of the role of interleukin-1 in airway inflammation.
The study of airway inflammation has traditionally been carried out by determining parameters of cellular influx to the airways. This approach is indirect and likely to miss the early stages of the pathogenesis. In this study we have developed a model in which interleukin-1 (IL-1) is increased in the airways of patients with chronic bronchitis and in which we can ask whether this is reflected in an alteration of the potential of the airway inflammatory response. The model involves the induction of a state of pulmonary inflammatory cell hyperplasia by a prior, low-dose exposure to asbestos. The cellular infiltrate comprises both eosinophils and neutrophils. We show here that in the patients with chronic bronchitis, both the eosinophil and neutrophil elements of the infiltrate express an increased potential for IL-1 synthesis, compared to that observed in control subjects with normal lung function. The increased expression of IL-1 activity by the bronchial infiltrate in patients with chronic bronchitis is, however, of a significantly lower intensity than that observed in a similar cell population from an unrelated disease, e.g. sarcoidosis. This difference in potential of the airway inflammatory response between the two groups may represent an underlying defect in patients with chronic bronchitis and is indicative of the need for further in-depth studies of immune factors in chronic airway inflammatory diseases.Tag: dha’wat
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